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Image of the Week

Image of the Week: aKNITomy

Image of the Week: aKNITomy

Vermont-based artisan Emily Stoneking admits to a scientific mind that’s less than well-tuned, but she’s being modest. Her aKNITomy collection — knitted interpretations of the innards of frogs, lab rats, earthworms and the human body — have attracted interest from both the National Museum of Health and Medicine in Washington, DC  and San Francisco’s Exploratorium.

The pieces channel Stoneking’s memories of high school biology class and those formaldehyde-scented hours spent hovering over dissections, which many of us share. But they also speak to her interest in history, specifically the Medieval period, where she notes that “people were dissecting things to find out how the world works” and ”the tendrils of scientific thought” can be found. It was this more humanist sensibility that motivated her to harness her knitting skills to create a softer version of science.

While the works are certainly cuddly, they aren’t entirely structurally correct because of difficulties in fitting in all the organs. “I do get notes from biologists saying, ‘I love what you do, but the biology’s wrong.’” she said. “If you really wanted to be accurate, that would be pretty [ghoulish]. What I’m after is something that’s just weird enough so people stop and say, ‘What’s that?’ So they stop and think.”

Patient Care, Stanford News, Videos

Stanford’s first cataract laser surgery patient shares her story

Stanford's first cataract laser surgery patient shares her story

As she approached 80, Mary Savoie knew it was time for cataract surgery. Cataracts, produced by the yellowing of the eyes’ lenses, were interfering with many of her favorite activities and prevented her from driving at night.

For decades, eye surgeons have practiced the circular incisions to gain access to those lenses and then used ultrasound to soften and remove them. But a new laser procedure has emerged that allows patients to return to their active lives with less pain and shorter recovery time.

Savoie is the first patient at the Byers Eye Institute at Stanford, and one of the first in the Bay Area, to have a cataract removed with the help of a laser. The technique involves making a precise circular incision guided by software mapping. The laser fractures the lens into tiny pieces, reducing the need for ultrasound intensity and duration in a way that cuts recovery time. Savoie had one cataract removed with the traditional approach and the other with the laser procedure. She shares her experience in the Stanford Hospital & Clinics video above.

Previously: To maintain good eyesight, make healthy vision a priority

Cancer, Stanford News, Technology, Videos

Stanford hospital patient turns to microwave ablation for “inoperable and incurable” tumors

Stanford hospital patient turns to microwave ablation for "inoperable and incurable" tumors

Interventional radiology, like its cousin interventional cardiology, is one of those medical specialties that runs along quietly without much fanfare until it does something that’s impossible in any other fashion. Surgery, even the minimally invasive sort that has traded big incisions for smaller ones, still has limitations — particularly in certain organs and for certain patients. Such was the case for Gwen McCane, a dynamo of a lady in her 70s, who had already passed successfully through chemotherapy and radiation for pancreatic cancer when tumors emerged deep in her liver. Any sort of surgery was just not possible, but interventional radiology offered her hope.

“The great thing is that we don’t need to make large incisions in our patients,” said Stanford interventional radiologist Gloria Hwang, MD, who treated McCane. “We can go in with just the poke of a needle.”

Guided by imaging, Hwang applied microwave heat to destroy the cancerous tissues. McCane went home the next day. “Every day we see people who have a real need, and they’re scared and they want to know they have options,” Hwang said. “My mission as a doctor is to offer them these options and to offer them newer, better ways of treating their cancers.”

Now McCane is back to playing golf, conducting self-esteem workshops at a county juvenile hall, meeting friends to play cards, working in her garden and being a sparkling companion to her husband of 50 years. “I feel good,” she said. “I’m just enjoying life.”

McCane’s story is captured in the Stanford Hospital video above.

Previously: New clues arise in pancreatic cancer from Stanford researchers

Cancer, Events, Stanford News, Women's Health

At Stanford event, cancer advocate Susan Love talks about “a future with no breast cancer”

At Stanford event, cancer advocate Susan Love talks about "a future with no breast cancer"

With conversations still fresh in the air about Angelina Jolie’s decision to remove her healthy breasts as a protective measure against a high probability of cancer, Susan Love, MD, cancer survivor and author of the best-selling book on breast cancer, couldn’t have been a more apt keynote speaker at the fourth annual Stanford Women’s Health Forum yesterday. She gave a forward-looking talk titled “A Future Without Breast Cancer: Where Are We and What Can We Do.”

We don’t understand the normal breast… If we’re really going to prevent breast cancer, we have to understand it

The forum was an event focused broadly on women’s health issues, but breast cancer and cancer survivorship were major topics – with many of the 400 attendees also hearing from Mark Pegram, MD, director of Stanford’s breast cancer program, and Allison Kurian, MD, an assistant professor of oncology at Stanford whose research is focused on hereditary breast cancer. (Kurian, in fact, had spent much of her day Tuesday answering questions from the press about Jolie.)

Love, who told the New York Times yesterday that she wants people to understand that “we really don’t have good prevention for breast cancer,” described to the audience how the state of knowledge about the breast and breast cancer is far from adequate. She said:

We don’t understand the normal breast… You’d think we’d know, but we really don’t. That’s a whole area that’s been ignored and it’s another thing we have to push people to do – to not just look at the disease. If we’re really going to prevent it, we have to understand how it works, to figure out what the early changes are. Isn’t it a shame that the only thing Angelina has to do, knowing she has the (mutant) gene, is to have a normal body part cut off – because we don’t know how to prevent breast cancer?

We’ve got awareness. We don’t have to work on that; we have to go beyond that to be part of finding the solution, to demand better research and to be part of it. I think we can be the generation that ends breast cancer.

Videos of this and other talks will be posted soon on the Stanford Center for Health Research on Women and Sex Differences in Medicine (WSDM) website.

Previously: Breast cancer advocate Susan Love to deliver keynote at Stanford Women’s Health Forum, Stanford’s Mark Pegram discusses breast cancer in the genomic age, Helping inform tough cancer-related decisions, BRCA patients use Stanford-developed online tool to better understand treatment options and A closer look at preventive breast cancer surgery

Autoimmune Disease, Chronic Disease, In the News, Obesity, Stanford News

The big downside of some life-changing medications

Several years ago, I listened in a state of semi-shock as a doctor gave me a classic bad news-good news combination: The autoimmune system disorder I had was incurable and life-threatening, but researchers had recently discovered that a certain package of medications could put it into remission. I remember that conversation well, but I don’t recall the doctor mentioning much, if anything, about the side effects of those medications.

At age 12, Jena Graves of Napa, Calif. faced the same serious situation. She was diagnosed with the autoimmune system disease lupus, and among her essential medications was the same steroid I was given, prednisone. It’s a go-to medication for millions who suffer from conditions including asthma and diabetes; it’s also on a short list of commonly prescribed “obesogenic” drugs whose effect on the body includes rapid weight gain.

Graves, just 5 feet 2 inches tall, shot up from 120 pounds to 272 pounds and developed Type 2 diabetes and other obesity-related health problems.

A colleague recently shared Graves’ story, which was told again in today’s San Francisco Chronicle. In the piece, Stanford’s John Morton, MD, who performed gastric bypass surgery on Graves this summer, raises a flag on behalf of patients like her:

“All these medications are absolutely wonderful when they work in the right patients,” [said Morton]. “But we’ve got to figure out if it’s appropriate or not to blanket America with prednisone and other obesity-generating drugs that are creating problems.”

Graves isn’t the only patient who has paid the price for being on one prescription too many, he said.

“I can’t tell you how many patients come in to see me who’ve been on medications for years,” he said. He asks: “Why are you on this medication? ‘I don’t know.’ Has someone followed up? ‘No. I just get my prescription refilled.”

Previously: When medications cause severe obesity

Cancer, Dermatology, Stanford News, Videos

The importance of sunscreen in preventing skin cancer

The importance of sunscreen in preventing skin cancer

For those of us who live in climes with no shortage of sunny days, spending hours outdoors is a such given that we may forget - especially in the bliss of summer vacation - that it can be too much of a good thing. But Stanford’s dermatologists, about to host their annual free skin cancer screening on June 2, are quick with facts and figures about the risks of too much unprotected time in the sun.

In the latest issue of Inside Stanford Medicine and in the video above, we tell the story of Kelly Bathgate – a classic example of what doctors are seeing in rising numbers: a young woman with melanoma. In the last 30 years, the rate of melanoma in women under age 40 has risen 150 percent. 

So how can these cancers be prevented? Since sun exposure remains the single most predictive risk factor for development of skin cancer, protective steps aren’t extreme. As Stanford physician Sumaira Aasi, MD, told me:

We’re not asking people to get on a treadmill or not eat their favorite foods. We’re just recommending that people treat sunscreen like brushing their teeth or using deodorant don’t leave the house without it no matter what the weather is like.

Previously: Study shows link between indoor tanning and common skin cancer, Working to prevent melanoma, New law: No more tanning beds for California teens and Intense, rapid sun tanning may increase skin cancer risk

Patient Care, Stanford News, Transplants, Videos

Given a second chance, lung transplant patient moves forward with gusto

Given a second chance, lung transplant patient moves forward with gusto

Chronic hypersensitivity pneumonitis, like other conditions that attack the lining of the lungs, has no known cure. Patient Jen Julian told me that when she was diagnosed, “I didn’t know if I was going to live or not. You face the reality of death.”

In the video above and in an article published today, we share the story of Julian, who was treated by physicians at Stanford’s recently established Center for Advanced Lung Disease. Julian received a transplant here and has since returned with gusto to all those things she did before – skiing, biking, hiking, golfing and scuba diving. Glenn Rosen, MD, director of the Interstitial Lung Disease program, said of his patient, “Jen has a unique attitude. She looks at the setbacks as challenges, tries new things and lives life to the fullest.”

Clinical Trials, Neuroscience, Research, Stanford News, Stem Cells

A stem cell trial halted, but the pursuit continues

A stem cell trial halted, but the pursuit continues

When Stanford neurosurgeon Gary Steinberg, MD, PhD, injected human stem cells this fall into the damaged spinal cord tissue of specially-selected patients, it was considered a major step forward in moving research discoveries toward clinical application. In November, however, the Menlo Park-based Geron Corp. announced it was ending the trial and its research into stem cells to concentrate on cancer drugs. Steinberg was disappointed, as many were. But, as he explained in a new Q&A on the Stanford Hospital & Clinics website:

We should remember that five of the anticipated eight total patients were successfully transplanted with no adverse effects noted to date. Since this was designed as a safety study, the outcomes are very encouraging. These patients will be followed for 15 years to assess continued safety as well as any signs of neurologic improvement. I don’t believe the early termination of enrollment in this study will significantly set back the stem cell therapy field.

And when asked about his personal motivation to pursue and study embryonic stem cell treatment, he told me:

I was inspired by what I see every day: Patients devastated by neurological disorders and psychiatric disease with no hope or little hope for recovery of function. And it’s been like that for hundreds of years for many neurological diseases or injuries, including stroke, degenerative disorders like Parkinson’s, brain tumors, Alzheimer’s. These patients are disabled and we have no treatment once the injury has occurred to restore or regenerate function. Stem cell therapy offers great hope to change that status for a large number of patients.

Previously: First California patient treated in Geron’s human embryonic stem cell trial and Stanford joins first human embryonic stem cell trial

Cancer, Men's Health, Stanford News, Videos

Making difficult choices about prostate cancer

Making difficult choices about prostate cancer

Gilbert Khalil’s exemplary fitness did not protect him against prostate cancer – after age 60, the risk rises for every man. Khalil, a project manager from Danville, took a very orderly approach to decide how to proceed after his diagnosis. He had watched his mother and brother endure the side effects of their cancer treatments, so he and his wife Stacee read everything they could. “They all had consequences,” he told me. “We decided we wanted to get a second or even a third opinion.” The couple ended up at Stanford, talking with Mark Gonzalgo, MD, PhD, director of robotic-assisted urologic cancer surgery. This video tells their story.

Media, Medical Apps, Medical Education, Stanford News

Can battling sepsis in a game improve the odds for material world wins?

Can battling sepsis in a game improve the odds for material world wins?

The first few times I played a new, Web-based and Stanford-designed medical game called Septris, all my patients died. After a few rounds, however, I felt my competitive fire ignite. And with a little more help from the game’s Dr. Sepsis, the better I became at treating sepsis (in the game, anyway), despite a lack of a medical degree. That degree of engagement is the whole point of the game, as I wrote in a story today:

Created by [Lisa Shieh, MD,] and a team of Stanford physicians, researchers and education technology experts, the game can be played on a mobile phone, a tablet such as an iPad, or a computer, and it represents a promising new approach to medical education. The idea is to plug knowledge about treating sepsis into the brains of clinicians who might find learning by digital game more appealing than a lecture, especially if they grew up with Nintendo, Playstation and Xbox. The name of this medical training tool is inspired by one of the world’s most popular computer games, Tetris.

The game’s designers wanted to keep the experience fun, despite the seriousness of the issue. Septris is free, unless players want to earn continuing medical education (CME) credits. In that case, there is a standard $20 CME test fee.

Previously: Rap video teaches how to recognize, treat sepsis in hospitals

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