"Check Tha' Tissue" is one of a number of pretty entertaining rap videos by ZDoggMD, which he describes as an "an original joint about the perils of over-the-counter pain medications." According to his profile page, ZDoggMD is:
...a hospital physician and purveyor of fine medical satire. On staff at a major academic institution, I strive to practice only evidence-based comedy...everything on this site has been clinically proven to be slightly funnier than placebo.
Dr. Dogg appears to be practicing in the Bay Area, but it's unclear where; some of the footage is shot at UCSF.