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Nutrition, Stanford News, Videos

Improving your health using herbs and spices

Can certain herbs and spices really boost immunity, control blood sugar, lower blood pressure and ease joint pain? As registered dietician Alison Ryan discusses in this Stanford Hospital & Clinics video, a growing body of scientific evidence suggests the answer is yes. During the 90-minute presentation, she explains in detail how ginger, turmeric, cinnamon and other ingredients can add a healthful punch to any meal, snack, or beverage by working to curb inflammation and prevent or delay certain types of cell damage. The talk is part of the Healthy Strides Ernest Rosenbaum Cancer Survivorship Lecture Series presented by the Cancer Supportive Care Program at Stanford.

Previously: How food may influence our cells and overall health and Nature/nurture study of type 2 diabetes risk unearths carrots as potential risk reducers

Aging, Genetics, Stanford News, Videos

Unlocking the secrets to human longevity

Unlocking the secrets to human longevity

Does the key to extending life lie within our genetic code? In this Stanford+Connects micro lecture, Stuart Kim, PhD, a professor of developmental biology and genetics, explains why he believes the answer is yes.

In his lab at Stanford, Kim and colleagues study functional genomics and aging and the search for genes that can either speed up or slow down aging, in particular with respect to the kidney. During this talk, he shares some of his lab’s advances in developmental biology in doubling the lifespan of a nematode, which is the world’s fastest-aging animal.

Previously: Male roundworms shorten females’ lifespan with soluble compounds, say Stanford researchers, Key to naked mole rat longevity may be related to their body’s ability to make proteins accurately, Longevity gene tied to nerve stem cell regeneration, say Stanford researchers and California’s oldest person helping geneticists uncover key to aging

Ask Stanford Med, Autoimmune Disease, Chronic Disease

Join Ask Stanford Med for a live discussion about scleroderma on Wednesday

Join Ask Stanford Med for a live discussion about scleroderma on Wednesday

hands_laptop_033114Although scleroderma is derived from the Greek words meaning “hardness” and “skin,” its symptoms affect far more than patients’ epidermis. The complex, rare disease can cause damage to the vascular system, lungs, kidneys and gastrointestinal tract with potentially life-threatening consequences.

On Wednesday at 4:30 PM Pacific time, we’ll be hosting an Ask Stanford Med Google+ Hangout about scleroderma research and progress being made to enhance patients’ quality of life. The live video discussion was organized in partnership with the Scleroderma Foundation and Inspire, a company that builds and manages online support communities for patients and caregivers.

Our panel of special guests includes Lorinda Chung, MD, director of the Scleroderma Center and co-director of the Multidisciplinary Rheumatologic Dermatology Clinic at Stanford; Karen Gottesman, patient services director for the Scleroderma Foundation of Southern California; and Melissa Warde, who was diagnosed with scleroderma at age 15 and has lived with the disease for more than two decades.

Panelist will address a range of topics, including:

  • Recent modifications to the disease criteria used in diagnosing scleroderma
  • The importance of patients being screened for pulmonary hypertension
  • The use of rating skin-thickness progression to help determine prognosis
  • A patient’s perspective on participating in a clinical trial
  • Efforts to develop online tools that enhance quality of life
  • Tips on how patients can live life to the fullest despite this debilitating disease

To participate in the discussion, watch the broadcast on the Stanford Medicine YouTube channel. A link to the hangout will also be tweeted on the @SUMedicine feed and posted on the School of Medicine’s Facebook page once the broadcast begins. Only panelists will be featured on screen, so audience members don’t need to be camera ready to join the conversation.

The public is welcome to submit questions for panelists in advance of the discussion by posting them in the comments section below before 3 PM Pacific time tomorrow (Tuesday). Questions can also be submitted during the live video discussion via Twitter using the hashtag #AskSUMed.

Previously: Save the date: Ask Stanford Med Google+ Hangout on Scleroderma April 2Another piece of the pulmonary-hypertension puzzle gets plugged into place, Patients with rare diseases share their extraordinary stories and Restoring hand function with surgery 
Photo by Judit Klein

Public Health, Videos

Exploring popular health myths and how they influence health-care decisions

Exploring popular health myths and how they influence health-care decisions

This week on the TEDMED Great Challenges series, guests discussed popular health myths, ways these myths spread. and how doctors and patients can better evaluate medical information. In the video above, Rusty Hoffman, MD, chief of interventional radiology at Stanford, addresses a variety of topics, including misconceptions related to heart disease and uncertainty around new mammogram guidelines, and discusses building trust between doctors and patients to dispel myths using evidence-based medicine.

Previously: European experts debunk six myths about flu shot, Four common myths about U.S. health care, Exploring popular sleep myths and MythBusters looks at pain myths with Stanford doctor on April 28

Health and Fitness, Health Disparities, Stanford News, Videos

AAMC’s Health Equity Research Snapshot features Stanford project on virtual health advisers

AAMC's Health Equity Research Snapshot features Stanford project on virtual health advisers

To improve public health, Stanford and academic medical centers around the country conduct research to identify solutions to systematic and preventable inequities in medicine and health care. A selection of these projects – including research led by Abby King, PhD, professor of health research and policy and of medicine – have been highlighted in the 2014 Health Equity Research Snapshot developed by the Association of American Medical Colleges (AAMC).

King and colleague Timothy Bickmore, PhD, with Northeastern University, are conducting ongoing research examining how virtual advisers can promote physical activity regardless of individuals’ level of education or language. Findings  published last August demonstrated how individuals who participated in an exercise program guided by the online coach had an eight-fold increase in walking compared with those who did not. In the above video, King explains how virtual advisers can be as effective as their human counter parts in promoting regular physical activity and can reach far larger groups of people in a more cost effective way.

In addition to King’s video, the snapshot features six others produced by health-equity researchers and their teams that represent work on a wide array of health outcomes and populations. The AAMC initiative is intended to demonstrate how research at every stage – from basic discovery to community-based participatory research – can contribute to closing or narrowing gaps in heath and health care.

Previously: Help from a virtual friend goes a long way in boosting older adults’ physical activity
Video still in featured-entry box by Relational Agents Group, Northeastern University

Ask Stanford Med, Autoimmune Disease, Chronic Disease

Save the date: Ask Stanford Med Google+ Hangout on Scleroderma April 2

Save the date: Ask Stanford Med Google+ Hangout on Scleroderma April 2

Updated 03-25-14: Readers are welcome to submit questions for our panelists in the comments section below. We’ll collect questions until 3 PM Pacific time on April 2. A selection of the questions will be answered during the live video conversation, which will be broadcast on the Stanford Medicine YouTube channel starting at 4:30 PM Pacific time. A future blog entry will provide details on how to watch the Google+ Hangout.

***

3-17-14: An estimated 300,000 Americans are living with scleroderma, a chronic connective tissue disease that is generally classified as one of the autoimmune rheumatic diseases. While hardening of the skin is the most visible manifestation of scleroderma, symptoms of the disease vary greatly among patients and the effects range from mild to life-threatening. Researchers are still working to determine the cause of scleroderma, and currently there is no cure for the disorder.

To foster conversation about this complex, rare disease, we’re partnering with the Scleroderma Foundation and Inspire, a company that builds and manages online support communities for patients and caregivers, for a Google+ Hangout about scleroderma research and progress being made to enhance patients’ quality of life. Among the panel of special guests are:

  • Lorinda Chung, MD, director of the Scleroderma Center and co-director of the Multidisciplinary Rheumatologic Dermatology Clinic at Stanford. Chung is actively involved in clinical, translational, and epidemiologic research on systemic sclerosis and related connective tissue disease, and she’s the principal investigator on a number of clinical trials of new potential therapies for scleroderma patients.
  • Karen Gottesman, patient services director for the Scleroderma Foundation of Southern California. Both a patient and a long-standing patient advocate, she is author of The First Year – Scleroderma, An Essential Guide for the Newly Diagnosed. Gottesman is also a member of the Scleroderma Patient-centred Intervention Network (SPIN), an international consortium of scientific researchers and clinicians organized to develop, test and disseminate psychosocial interventions to improve the quality of life for scleroderma patients worldwide.

Audience members are welcome to submit questions during the live video discussion via Twitter using the hashtag #AskSUMed. Please save the date and join us on April 2 at 4:30 PM Pacific Time.

Previously: Another piece of the pulmonary-hypertension puzzle gets plugged into place, Rules for living with a chronic illness, Patients with rare diseases share their extraordinary stories and Restoring hand function with surgery

Medical Education, Medical Schools

Using digital resources to redefine the medical education model

iPad_032514Today on MedCrunch, Stanford medical school alumna Stesha Doku, MD, examines how digital resources can enhance the traditional medical school curriculum to ” help health-care professionals succeed in their goals to deliver quality care.” Highlighting online learning sites such as PodMedics, which offers medical and surgical video tutorials, Doku writes:

What we gain from the growth of such applications and more general sites such as Khan Academy is that the physical classroom is becoming less relevant. It’s not so much a question of the classroom being not enough, but rather if the classroom is the correct place to deliver our learning materials in the first place. If so, are we delivering distilled and most importantly relevant information?

While we value those who are ‘smart’ in medicine, we must make more effort to value those who can translate their knowledge into improving outcomes and progressing our field. This may mean spending less time on acquiring knowledge that has no application. This may also require spending more time practicing application.

As reported previously on Scope, the School of Medicine is developing the Stanford Medicine Interactive Learning Initiatives, which utilizes the “flipped classroom” model to make better use of the fixed amount of educational time available to train doctors.

Previously: Social learning in a medical photo-sharing app for doctors, A closer look at using the “flipped classroom” model at the School of Medicine, Combining online learning and the Socratic method to reinvent medical school courses, Using the “flipped classroom” model to re-imagine medical education and Rethinking the “sage on stage” model in medical education
Photo by Stanford Ed Tech

Autism, In the News, Pediatrics, Research, Stanford News

Inspired by his autistic son, a Stanford researcher works to understand the biochemistry of autism

Inspired by his autistic son, a Stanford researcher works to understand the biochemistry of autism

dolmetschIn a Q&A published today in the New York Times, Stanford neurobiologist Ricardo Dolmetsch, PhD, tells reporter Claudia Dreifus that his immediate reaction to learning his son was diagnosed with autism was, “We’re not going to leave any stone unturned to help him.”

Leaving no stone unturned included changing the focus of his research to better understand the biochemistry of autism and leading an effort to create a technique that involves reprogramming skin cells from autistic children into neurons. As reported previously on Scope, this approach allows scientists to better study brain function in children with autism.

Dolmetsch, who is currently on leave from Stanford and working at Novartis, tells Dreifus that his main goal is to develop new pharmaceutical therapies for autism. When she asked him how he identifies patients to participate in his research, he responded:

Through social media. We’re often interested in groups or families who have specific kinds of mutations. Some of them are rare — 5,000 people worldwide.

So we have a committee that decides what’s the next mutation we’re going to work on. Then we find children with it. It used to be we’d spend half of our budget locating people. Now, we go to the families with a Facebook page for people with X, Y, or Z mutation. Then I’ll post a call. Parents will come forward.

The aim is to develop a database of the mutations we think are causative of the neuropsychiatric diseases. If we can get samples through stem-cell-derived neurons and create a library of them, we could change the way the diseases are diagnosed.

Previously: Using stem cells to advance autism research, Stanford Magazine spotlights scientists’ efforts to untangle the root causes of autism and Research on autism is moving in the right direction
Photo by Steve Fisch

Events, Genetics, Stanford News, Technology

Euan Ashley discusses harnessing big data to drive innovation for a healthier world

Euan Ashley discusses harnessing big data to drive innovation for a healthier world

Euan_AshleyElectronic patient records, clinical trials, DNA sequencing, and medical imaging and disease registries are a sampling of the sources contributing to the exponential growth of public databases housing biomedical information. Researchers hope mining this vast reservoir of data will accelerate the process of understanding disease while driving down the costs of developing new therapies.

But the challenge of harnessing big data to transform scientific research and improve human health is one that is so complex that it can’t be solved alone by a single person, institution or company; collaboration among government, academia and industry is imperative. To foster such partnerships, Stanford and Oxford University are sponsoring the Big Data in Biomedicine conference from May 21-23.

The conference is part of a big data initiative launched by Stanford and Oxford to solve large-number problems at a global scale to improve health worldwide. Euan Ashley, MD, who directs the effort at Stanford, has been involved in several major projects over the past few years to link an individual’s genome sequence to possible increases in disease risk. In the following Q&A, he shares insights about the upcoming conference program, provides an update on the initiative, and discusses how big data can drive innovation for a healthier world.

A collaborative effort between Oxford and Stanford aims to accelerate discovery from large-number data sets to provide new insight into disease and to apply targeted therapies on an unprecedented scale. In what ways are the universities currently working together to achieve this goal?

The Global Institute for Human Health Initiative is a very exciting new venture between these two universities. Catalyzed by the Li Ka Shing Foundation, the initiative draws on the complementary strengths of each institution. Stanford excels in innovation, technology and data management and analysis. Oxford has global reach through its School of Public Health. So it makes sense to work together.

One of our primary goals will be to build “bridges” between the largest databanks of health information in the world. These individual large-scale efforts are remarkable in their own way, but each one has by definition to focus primarily on its own data. This means that limited bandwidth is available to develop mechanisms of secure sharing and analysis. That bandwidth and expertise are things we hope to provide through the initiative. The seed grants awarded through our program in Data Science for Human Health are another way we have started to collaborate. Each one has an Oxford-Stanford collaboration at its heart.

Tell us more about those seed grants. How many have you awarded, and for what kinds of projects?

We received 60 applications and were able to award 12 grants totaling $807,171.48. Among the projects receiving funding were new methods for analyzing accelerometer data in smartphones, approaches to imaging data, and ideas for large scale data analysis, point of care testing for infectious disease and mobile application development. It was an amazing group of applications and I wish we could have funded more projects. At the conference, there will be a brief satellite meeting for the recipients to interact.

Let’s talk more about the upcoming conference. What else can attendees expect from it?

We have an exciting program with a number of high-profile speakers. I’m particularly pleased this year with the broad representation of presenters across sectors. There will be speakers across government, industry and academia, including representatives from the National Institutes of Health, Google, Intel, Mount Sinai and Duke.

We’ve also expanded our international reach, and one of the keynote speeches will be delivered by Ewan Birney, director of the European Bioinformatics Institute. Additionally, this year’s program includes two new topic areas: computing and architecture, which will be chaired by Hector Garcia Molina, PhD, and infectious disease genomics, a particular strength at Oxford. Another addition is the Big Data Corporate Showcase, where companies ranging from industry giants to start-ups will share their achievements and innovations related to big data. So, lots to look forward to!

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Mental Health, Research

Study finds happy employees are 12 percent more productive

Google_officePast research has shown that work stress compromises your personal health and is a contributing factor to rising health-care costs. Now a new study shows that increased happiness can boost worker productivity without sacrificing quality.

Researchers at the University of Warwick performed four different experiments with more than 700 participants. During the study, some individuals were shown a clip of a comedic film or were provided with free chocolate, drinks and fruit. Other groups were asked about recent family tragedies, such as bereavement. Futurity reports:

In the laboratory, they found happiness made people about 12 percent more productive.

“The driving force seems to be that happier workers use the time they have more effectively, increasing the pace at which they can work without sacrificing quality,” [says Daniel Sgroi, DPhil.]

Noting how employee perks at Google helped the company increase worker productivity, the authors say the findings offer compelling evidence that companies should “strive to make their workplaces emotionally healthy for their workforce.”

On a related note, this Stanford Graduate School of Business video explores the profound impact laughter can have on our brains, bodies and behavior. In the talk, MBA candidate Eric Tsytsylin discusses why individuals and organizations should embrace humor and laughter as a way of boosting happiness, creativity and productivity.

Previously: Are you happy now? Stanford Roundtable spotlights the science of happiness and wellbeing, For a truly happy New Year, cultivate sustainable happiness, Study suggests specific gene may influence happiness among women and TED Talk with Laura Carstensen shows older adults have an edge on happiness
Photo by Scott Beale

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