This kaleidoscope-esque video depicts the immune response in the lymph node of a mouse. Titled "Sensing Danger," the clip won first place in this year's Small World in Motion Photomicrography Competition by Nikon Instruments. It was produced in the Laboratory of Immunoregulation at the National Institute of Allergy and Infectious Disease.
From the Nikon release:
This video is representative of efficient innate immune reaction in the lymph node, which typically has been studied for the development of adaptive immune response.
The inguinal lymph node was imaged using a two-photon microscope equipped with an L25.0 x 0.95 water immersion objective. Together, this allowed for the visualization of actual events occurring in challenged lymphatic tissue.
Second place was awarded to a video capturing sperm from two males competing within reproductive tract of a female fruit fly. Footage of a metanephric kidney, cultured in vitro and imaged over four days took third place.